This article explains the layering options in the Epson SC-S80600 driver.
Inkset:
First of all, in order to be able to print in multiple layers you need to select a layering inkset:
Color = Color only
Color + White = Color & White in one layer
Color + White 2 Layers = Color & White in two separate layers
Color + White 3 Layers 1 way = Color + White in three separate layers, but viewed in 1 direction:
Color + White 3 layers 2 way = Color + White in three separate layers, but viewed in 2 directions(Sandwich printing):
Color + metallic = Color + Metallic in on layer
Color + metallic = Color + Metallic in 2 separate layers
Layer Image mode
As well as the inkset option above, you also need to determine the viewing direction of your print mode either in Surface or Reverse: